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Project: Identification and characterization of genes involved in neuroblastoma.

project duration
01-OCT-97 – 30-SEP-01
abstract
This project aims at the identification and characterization of genes involved in the development of neuroblastoma. After isolation of differentially expressed transcripts by means of suppression sutractive hybridization, the differential expression status will be verified by Northern blotting, quantitative PCR, reverse Northern and micro-array analysis. The relevancy of verified genes in neuroblastoma biology will be determined by expressionprofiling of genetic subtypes of this tumor and the normal cellular counterparts in the embryonic adrenal medulla.