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Project: Identification and characterisation of cell surface factors that mediate positive selection and terminal maturation of thymocytes.

project duration
01-OCT-97 – 07-FEB-01
abstract
Multiple lines of evidence suggest that TCR/MHC interactions are required but are not sufficient during thymocyte development. Experiments showed that freshly isolated TEC, but not cultured TEC, could restore their capacity to mediate positive selection. The aim of this project is to identify molecules other than TCR/CD4/CD8/ and MHC that contribute to positive selection and functional maturation of thymocytes.