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Project: Evaluation of the functions and differential regulation(s) of adseverin, adseverin(D5) and gelsolin, three members of the gelsolin family.

project duration
01-OCT-97 – 30-SEP-01
abstract
The actin microfilamentsystem in a cell is regulated by numerous actin binding proteins. Adseverin, adseverin(D5) and gelsolin, three members of the gelsolin family, are simultaneously present in a single cell. We therefore think that these three proteins are differentially regulated or have other functions than actin binding. We will study this isolating binding partners using the yeat two hybrid system and affinity chromatography.