Project: Phenotype and function of the airway DC and his importance in the pathogenesis of the allergic airway iflammation in the rat.
- project duration
- 01-JAN-97 – 31-DEC-00
- This project will investigate the importance of the airway dendritic cell in the skewing of the immune response towards Th2 cytokine production (IL-1Beta, IL-4, IL-5, IL-6 and IL-12) and the development of allergy in a rat model of allergic airway inflammation. Cytokine mRNA expression will be measured by quantitative RT-PCR. Then we want to modify the fenotype and cytokine synthesis of the DC.