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Project: In vivo regulation of colifin, an essential protein in actin dydnamics, by interaction with phosphatidylinositol-4,5-bisphosphate.

project duration
01-OCT-01 – 30-SEP-05
abstract
In this project, we will study the in vivo regulation of cofilin - an essential protein in actin dynamics - by interaction ith phosphatidylinositol-4,5-bisphosphate. A comparative cell biological study, based on the use of mutant cofilin constructs, will elucidate the in vivo role op PIP2 in the activity of cofilin on actin and on its regulation by phosphorylation.