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Project: Physico-pharmaceutical study of the penetration of macromolecular drugs through cystic fibrosis sputum.

project duration
01-OCT-97 – 30-SEP-01
abstract
Cystic Fibrosis (CF) is characterized by the presence of a viscoelastic mucus layer in the upper airways of CF patients. The underlying problem is a mutation in the gene encoding for the Cystic Fibrosis Transmembrane conductance Regulator (CFTR) protein. Clinical studies considering gene transfer for CF are ongoing. The main objective of this project is to elucidate the extent to which CF sputum presents a diffusion and physiochemical barrier towards CF gene therapy.