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Project: Heat shock protein-based modulation of vaccination efficiency against rainbow trout fry syndrome (RTFS) in rainbow trout (Oncorhynchus mykiss, Walbaum, 1792)

project duration
01-JAN-06 – 31-DEC-07
abstract
Disease outbreaks are considered am ajor constraint to the full development of the aquaculture sector worldwide. Because the use of conventional approaches such as antibiotics is associated with many problems, there is a tendency to use profylactic treatments. The PhD project will investigate whether heat shock proteins (HSPs) can be used to stimulate non-specific immune response or as vaccine adjuvants. HSPs are a family of evolutionally conserved "housekeeping" molecules that play fundamental roles in assisting proeitn folding and unfolding. Furthermore, scientists have shown that HSPs modulate the immune response and that they can be used as adjuvants.