Project: Identification and characterization of autoantigens in rheumatoid arthritis and related rheumatic connective tissue diseases.
- project duration
- 01-JUL-97 – 31-DEC-99
- The research partners will identify and characterize on a molecular level serological markers that are useful in the context of rheumatoid arthritis and related connective tissue diseases. A special focus will be on the correlation between the clinical phenotype and the fine autoimmune serology. Antigens with important diagnostic relevance will be cloned and made available for immuno essays. In specific cases epitope mapping will be performed in order to replace the cloned protein by synthetic peptides.