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Project: High sensitivity structure determination of proteins. The organisation of the actin cytoskeleton and control of directional cell migration.

01-JAN-95 – 31-DEC-99

Techniques will be developed that allow protein primary structure determination in the femtomole range. These methods will be used to identify components in the signal transduction pathway leading to actin cytoskeleton organization. The third part aims at identifying genes and the signal transduction pathways involved in the control of the directionality of cell migration.