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Project: Generation of a transgenic model system in Xenopus tropicalis serving as a platform for the identification of new therapeutic components and the isolation of primary targets of singaling pathways involved in human pathologies

01-JAN-02 – 31-DEC-05

Design of transgenic system in frog embryos for drug and mutagenesis screens. Genetically modified frogs are generated, based on the intergration of regulatory DNA sequences driving expression of fluorescent proteins, that can function as a complex reportersystem. Spatiotemporally controlled activation of signaling pathways should generate animals that are "sensitized" for a certain pathology and, as such, function to model diseases.