This project aims to exploit the new possibilities of array CGH for human genetic diagnosis. A first aim is the development o fsingle cell array CGH analysis for preimplantation genetic diagnosis and possibly the diagnosis of certain types of tumors. A further aim is to apply array CGH methodology in the area of constitutional and cancer epigenetics. Lastly, these studies will generate a huge amount of novel (biological) information and will require novel bioinformatics appraoches to aid clinicians and laboratory directors in decision making and help researchers in understanding their findings. Therefore data storage, visualization and analysis tools will be further developed for the different applications.