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Project: Development of metabolomic tools: MALDI-MS for small molecules

project duration
01-OCT-03 – 30-SEP-05
abstract
This study contains two objectives: on the one hand, we will optimize the analysis of small molecules by MALDI mass spectrometry. Several matrices will be examined in function of their ionisation efficiency, matrix interference, reproducibility and robustness. Matrix-free desorption techniques will also be discussed. On the other hand, we will use this technique, based on MALDI and accurate mass analysis, in the field of metabolomics. By using this method in combination with multivariate techniques, we will be able to distinguish groups based on their differences on the metabolite level.