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Project: Analysis and mining of signaling complexes using contemporary interactomics

01/04/12 – 30/09/17

Protein interactions fulfil a critical role in a cell and their dysregulation contributes to human disease. We will apply an unique technology “toolbox” comprising MAPPIT, PPI-iMixPro and VIROTRAP, combined with state-of-the-art bioinformatics approaches, to gain new insights into the (patho)fysiological roles of selected protein interactions. In addition, we will use nanobodies as intrabodies to disturb protein interactions in cellulo.