Project: Molecular networks of cancer invasion.
- project duration
- 01-JAN-00 – 31-OCT-06
- Cell biology of cancer invasion is dominated by the molecular crosstalk between gentically altered cancer cells and micro-environmental factors. Posttranslational modifications of the E-cadherin/catenin invasion-suppressor complex are crucial. We shall analyse the role of E-cadherin ectodomain shedding. Next to this paracrine factor we analyse also paracrine elements: natural mediators, myofibroblasts, micro-organisms.