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Project: Molecular networks of cancer invasion.

project duration
01-JAN-00 – 31-OCT-06
abstract
Cell biology of cancer invasion is dominated by the molecular crosstalk between gentically altered cancer cells and micro-environmental factors. Posttranslational modifications of the E-cadherin/catenin invasion-suppressor complex are crucial. We shall analyse the role of E-cadherin ectodomain shedding. Next to this paracrine factor we analyse also paracrine elements: natural mediators, myofibroblasts, micro-organisms.