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Project: Molecular signaling and modulation of mitochondrial functions during cell death

project duration
01-JAN-02 – 31-OCT-09
abstract
Mitochondria are crucial in apoptotic and necrotic cell death. The project aims at unraveling the molecular signaling by an in vitro reconstitution on isolated mitochondria. We will also molecularly analyze the modulatory influence of metabolic cellular conditions (hypoxia, ER stress, energy metabolism) on mitochondrial functioning in cell death. An important aspect concerns the proteome analysis of mitochondrial subfractionations in various metabolic conditions.