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Project: Eicosanoid and T-cell inflammatory network in chronic rhinosinusitis/ nasal polyposis and aspirin exacerbated disease (AERD).

project duration
01-OCT-07 – 30-SEP-10
abstract
Aspirin exacerbated disease is characterized by a Th2 mediated, eosinophilic inflammation and by imbalance of the eicosanoid pathway. Additionally we suggest that deficiency in T-reg suppression may play an important role in the manifestation of the disease. Based on that we aimed to study the phenotype and the regulation of T-cells/TCR and the influence of eicosanoids on T-cell differentiation/activation in CRS/NP-AERD patients.