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Project: Analysis of the mechanism of butyric acid mediated decrease in virulence of Salmonella

project duration
01-OCT-05 – 30-SEP-08
abstract
Salmonella is one of the major bacterial zoonotic pathogens, related to consumption of animal products. Invasion in intestinal epithelial cells is considered to be crucial in the pathogenesis of the infection. It is known that invasion is decreased by butyric acid contact. In this project, a study will be carried out to identify the genes involved in the butyric acid mediated decrease in virulence. Genes that are down- or upregulated after contact with butyric acid will be deleted in the Salmonella genome, and it will be checked whether the butyric acid mediated decrease in virulence is still present.