Project: Understanding the immunological basis of persistent airway obstruction in asthma

2021-01-01 – 2027-12-31

Abstract

In severe asthma, there is persistent obstruction of the airways with mucus plugs containing mucins, fibrin, and Charcot-Leyden crystals. We hypothesize that plugged airways constitute a unique niche where type 2 immune cells thrive and communicate with structural cells to perpetuate disease. We will
study if eliminating plugs or key niche communication signals can treat persistent disease in mouse and man.