Project: Cell death activity regulation in inflammation and cancer
2009-01-01 – 2027-09-30
- Abstract
The project aims at a global and integrated approach of the 4 major types of cell death (apoptosis, necrosis, autophagic cell death, pyroptosis) on four levels: the biochemistry of caspases and RIP kinases, the intracellular signal transduction, the intercellular communication and its role in experimental diseaese models using transgenic animals. We will use global approaches involving shRNA, siRNA and miRNA screenings, interactomics, degradomics, phosphoproteomics and bioinformatics.
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Harnessing luciferase chemistry in regulated cell death modalities and autophagy : overview and perspectives
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- Journal Article
- A1
- open access
The thymus road to a T cell : migration, selection, and atrophy
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- Journal Article
- A1
- open access
Metabolite-based inter-kingdom communication controls intestinal tissue recovery following chemotherapeutic injury.
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- Journal Article
- A1
- open access
Ferroptosis in health and disease
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- Journal Article
- A1
- open access
The autophagy protein RUBCNL/PACER represses RIPK1 kinase-dependent apoptosis and necroptosis
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- Journal Article
- A1
- open access
TL1A and IL-18 synergy promotes GM-CSF-dependent thymic granulopoiesis in mice
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- Journal Article
- A1
- open access
Need for standardization of Influenza A virus-induced cell death in vivo to improve consistency of inter-laboratory research findings
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- Journal Article
- A1
- open access
RIPK1 protects naive and regulatory T cells from TNFR1-induced apoptosis
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- Journal Article
- A1
- open access
Type 1 immunity enables neonatal thymic ILC1 production
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- Journal Article
- A1
- open access
A guide to the expanding field of extracellular vesicles and their release in regulated cell death programs