Project: STOP SEPSIS

2021-01-01 – 2027-12-31

Abstract: With 30 million cases, 8 million deaths (3 million children) yearly, sepsis (strongly underfunded) is a huge medical problem. We suggest the innovative principle that sepsis is a failing starvation response which is based on failing key molecules (identified by us) in the liver. The mechanism of their failure, the consequences and therapeutics following form the basis of this project.

Add to list
- Journal Article
- open access
Comparative Analysis of Hepatic Gene Expression Profiles in Murine and Porcine Sepsis Models

Fëllanza Halimi (UGent) , Tineke Vanderhaeghen (UGent) , Steven Timmermans (UGent) , Siska Croubels (UGent) , Claude Libert (UGent) and Jolien Vandewalle (UGent)

(2024) INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 25(20).
Add to list
- Journal Article
- open access
Sepsis-induced changes in pyruvate metabolism: insights and potential therapeutic approaches

Louise Nuyttens (UGent) , Jolien Vandewalle (UGent) and Claude Libert (UGent)

(2024) EMBO MOLECULAR MEDICINE. 16(11). p.2678-2698
Add to list
- Journal Article
- A1
- open access
A critical role for HNF4α in polymicrobial sepsis-associated metabolic reprogramming and death

Céline Van Dender (UGent) , Steven Timmermans (UGent) , Ville Paakinaho, Tineke Vanderhaeghen (UGent) , Jolien Vandewalle (UGent) , Maarten Claes (UGent) , Bruno Garcia, Bart Roman (UGent) , Jan De Waele (UGent) , Siska Croubels (UGent) , et al.

(2024) EMBO MOLECULAR MEDICINE. 16(10). p.2485-2515
Add to list
- Journal Article
- A1
- open access
Identification and characterization of multiple Paneth cell types in the mouse small intestine

Steven Timmermans (UGent) , Charlotte Wallaeys (UGent) , Natalia Garcia Gonzalez (UGent) , Lotte Pollaris (UGent) , Yvan Saeys (UGent) and Claude Libert (UGent)

(2024) CELLS. 13(17).
Add to list
Paneth cell TNF signaling induces gut bacterial translocation and sepsis

Charlotte Wallaeys (UGent) , Natalia Garcia Gonzalez (UGent) , Steven Timmermans (UGent) , Jolien Vandewalle (UGent) , Tineke Vanderhaeghen (UGent) , Somara De Beul (UGent) , Hester Dufoor (UGent) , Melanie Eggermont (UGent) , Elise Moens (UGent) , Victor Bosteels (UGent) , et al.

(2024) CELL HOST & MICROBE. 32(10). p.1725-1743
Add to list
- Journal Article
- A1
- open access
Crosstalk interactions between transcription factors ERRα and PPARα assist PPARα-mediated gene expression

Sofie Desmet, Jonathan Thommis (UGent) , Tineke Vanderhaeghen (UGent) , Edmee Vandenboorn, Dorien Clarisse (UGent) , Yunkun Li, Steven Timmermans (UGent) , Daria Fijalkowska (UGent) , Dariusz Ratman (UGent) , Evelien Van Hamme (UGent) , et al.

(2024) MOLECULAR METABOLISM. 84.
Add to list
- Journal Article
- A1
- open access
The impact of hepatocyte-specific deletion of hypoxia-inducible factors on the development of polymicrobial sepsis with focus on GR and PPARα function

Tineke Vanderhaeghen (UGent) , Steven Timmermans (UGent) , Melanie Eggermont (UGent) , Deepika Watts, Jolien Vandewalle (UGent) , Charlotte Wallaeys (UGent) , Louise Nuyttens (UGent) , Joyca De Temmerman, Tino Hochepied (UGent) , Sylviane Dewaele (UGent) , et al.

(2023) FRONTIERS IN IMMUNOLOGY. 14.
Add to list
- Journal Article
- A1
- open access
Mousepost 2.0, a major expansion of the resource

Steven Timmermans (UGent) , Jolien Vandewalle (UGent) and Claude Libert (UGent)

(2023) NUCLEIC ACIDS RESEARCH. 51(4). p.1652-1661
Add to list
- Journal Article
- A1
- open access
Hepatic peroxisome proliferator-activated receptor alpha dysfunction in porcine septic shock

Jolien Vandewalle (UGent) , Bruno Garcia, Steven Timmermans (UGent) , Tineke Vanderhaeghen (UGent) , Lise Van Wyngene, Melanie Eggermont (UGent) , Hester Dufoor (UGent) , Céline Van Dender (UGent) , Fëllanza Halimi (UGent) , Siska Croubels (UGent) , et al.

(2022) CELLS. 11(24).
Add to list
- Journal Article
- A1
- open access
Sepsis : a failing starvation response

Jolien Vandewalle (UGent) and Claude Libert (UGent)

(2022) TRENDS IN ENDOCRINOLOGY AND METABOLISM. 33(4). p.292-304

Academic Bibliography

Project: STOP SEPSIS

Comparative Analysis of Hepatic Gene Expression Profiles in Murine and Porcine Sepsis Models

Sepsis-induced changes in pyruvate metabolism: insights and potential therapeutic approaches

A critical role for HNF4α in polymicrobial sepsis-associated metabolic reprogramming and death

Identification and characterization of multiple Paneth cell types in the mouse small intestine

Paneth cell TNF signaling induces gut bacterial translocation and sepsis

Crosstalk interactions between transcription factors ERRα and PPARα assist PPARα-mediated gene expression

The impact of hepatocyte-specific deletion of hypoxia-inducible factors on the development of polymicrobial sepsis with focus on GR and PPARα function

Mousepost 2.0, a major expansion of the resource

Hepatic peroxisome proliferator-activated receptor alpha dysfunction in porcine septic shock

Sepsis : a failing starvation response

Contents

Support

Contact