Project: Interaction of alphaherpesviruses with natural killer (NK) cells
- project duration
- 01-MAY-10 – 28-FEB-15
- NK cells are crucial in the immune response against alphaherpesviruses. We will investigate whether viral glycoproteins gB, gC, and gD influence NK cell activity through interaction with inhibitory/activating receptors, and whether the viral US3 protein kinase interferes with NK-mediated cell lysis. This will generate new insights in the immune response against alphaherpesviruses, which may lead to new antiviral strategies.