Project: Exploration of the function of ZAP-70 in lymphoid malignancies
- project duration
- 01-JAN-06 – 31-OCT-10
- The role of ZAP-70 in lymphoid malignancies is analysed starting from the model of B-cell chronic lymphocytic leukaemia (B-CLL). The influence on phosphorylation of Syk and related kinases, apoptosis and the in vivo behaviour of B-CLL cells. The observations will be tested on their universality in other lymphoid malignancies.