Project: Autophagy in inflammation and inflammatory disorders (ATLANTIS), from basic insights to experimental therapy
2021-01-01 – 2024-12-31
- Abstract
Autophagy is crucial in the (patho)physiology, including inflammation, infection and cancer. Autophagy functions as a survival mechanism by maintaining viability during periods of stress, and by removing damaged organelles and toxic metabolites, such as protein aggregates or intracellular pathogens. The Atlantis research consortium (AuTophagy in InfLAmmatioN and inflammaTory dISorders) brings together a team of expert investigators from the complementary fields of autophagy, (cancer) cell death signaling, inflammation signaling, angiogenesis and atherosclerosis, and drug screening and medicinal chemistry. We will study in an integrated way the impact of autophagy and its pharmacological modulation in various vascular diseases with a focus on the endothelium and its functional interaction with immune cells in sepsis, tumor-driven (lymph)angiogenesis, and atherosclerosis.
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RIPK1 kinase-dependent inflammation and cell death contribute to the pathogenesis of COPD
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Tyramide signal amplification for the immunofluorescent staining of ZBP1-dependent phosphorylation of RIPK3 and MLKL after HSV-1 infection in human cells
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ATG9A prevents TNF cytotoxicity by an unconventional lysosomal targeting pathway.
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- Journal Article
- open access
Phosphorylation of RIPK1 serine 25 mediates IKK dependent control of extrinsic cell death in T cells
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Spectrally tunable Förster resonance energy transfer-based biosensors using organic dye grafting
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- Journal Article
- A1
- open access
ADAR1 prevents autoinflammation by suppressing spontaneous ZBP1 activation
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- Journal Article
- A1
- open access
Cancer cells dying from ferroptosis impede dendritic cell-mediated anti-tumor immunity
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- Journal Article
- A1
- open access
Association of cell death markers with tumor immune cell infiltrates after chemo-radiation in cervical cancer
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- Journal Article
- A1
- open access
MLKL deficiency in BrafV600EPten-/- melanoma model results in a modest delay of nevi development and reduced lymph node dissemination in male mice
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- Journal Article
- A1
- open access
Reduced protection of RIPK3-deficient mice against influenza by matrix protein 2 ectodomain targeted active and passive vaccination strategies