Project: Unlocking powerful non-model organisms in microbial synthetic biology - POSSIBL
2021-01-01 – 2024-12-31
- Abstract
Synthetic biology is a new discipline that allows designing and creating novel, completely man-made biological systems such as metabolic pathways. The innovative technology is a game-changer for the sustainable production of pharmaceuticals, biofuels, enzymes, aroma compounds and bioplastics. The
synthetic systems are often implemented in E. coli or yeast cells because the biotechnological toolbox for these organisms is readily available. However, these microbes are often not optimally suited for industrial or medical applications. This project therefore aims to develop a novel toolbox that allows
the ethical exploitation of superior non-standard microbes. The project will not only yield an important breakthrough for the efficiency and possibilities of synthetic biology, but also constitutes a research consortium of a team of young and ambitious scientists that will serve as a strategic hub for the further
development of synthetic biology in Flanders, thereby helping to maintain its leading position in biotech.
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Unlocking the potential of non-model bacteria : development of a cross-bacterial gene expression toolbox
(2025) -
Art–science collaborations in biotechnology research : a transdisciplinary approach
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A cross-bacterial gene expression toolbox : engineering orthogonal transcription to enable predictable genetic engineering in diverse bacterial hosts
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- Journal Article
- A1
- open access
Assessing the transcriptional landscape of Pseudomonas phage 201ϕ2-1 : uncovering the small regulatory details of a giant phage
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- Journal Article
- A1
- open access
Delaying production with prokaryotic inducible expression systems
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- Journal Article
- A1
- open access
Towards a rational approach to promoter engineering : understanding the complexity of transcription initiation in prokaryotes
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- Journal Article
- A1
- open access
Transcriptional and translational dynamics underlying heat shock response in the thermophilic crenarchaeon Sulfolobus acidocaldarius
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- Journal Article
- A1
- open access
Standardization of fluorescent reporter assays in synthetic biology across the visible light spectrum
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- Journal Article
- A1
- open access
Taming CRISPRi : dynamic range tuning through guide RNA diversion
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- Journal Article
- A1
- open access
MoBioS : modular platform technology for high-throughput construction and characterization of tunable transcriptional biological sensors