Project: Unlocking powerful non-model organisms in microbial synthetic biology - POSSIBL
2021-01-01 – 2024-12-31
- Abstract
Synthetic biology is a new discipline that allows designing and creating novel, completely man-made biological systems such as metabolic pathways. The innovative technology is a game-changer for the sustainable production of pharmaceuticals, biofuels, enzymes, aroma compounds and bioplastics. The
synthetic systems are often implemented in E. coli or yeast cells because the biotechnological toolbox for these organisms is readily available. However, these microbes are often not optimally suited for industrial or medical applications. This project therefore aims to develop a novel toolbox that allows
the ethical exploitation of superior non-standard microbes. The project will not only yield an important breakthrough for the efficiency and possibilities of synthetic biology, but also constitutes a research consortium of a team of young and ambitious scientists that will serve as a strategic hub for the further
development of synthetic biology in Flanders, thereby helping to maintain its leading position in biotech.
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Non-model bacteria as platforms for endogenous gene expression in synthetic biology
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- Journal Article
- A1
- open access
Expanding the quorum sensing toolbox : promoter libraries and hybrid promoter for dynamic genetic circuits
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- Journal Article
- A1
- open access
Characterization and orthogonality assessment of two quorum sensing systems for synthetic biology applications
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To transcription and beyond : development and application of transcriptional tools for yeasts and archaea
(2025) -
- Journal Article
- A1
- open access
Effects of genomic location on ectopic integration and gene expression of a reporter gene cassette in Sulfolobus acidocaldarius
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Unlocking the potential of non-model bacteria : development of a cross-bacterial gene expression toolbox
(2025) -
- Journal Article
- A1
- open access
Art–science collaborations in biotechnology research : a transdisciplinary approach
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A cross-bacterial gene expression toolbox : engineering orthogonal transcription to enable predictable genetic engineering in diverse bacterial hosts
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- Journal Article
- A1
- open access
Assessing the transcriptional landscape of Pseudomonas phage 201ϕ2-1 : uncovering the small regulatory details of a giant phage
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- Journal Article
- A1
- open access
Delaying production with prokaryotic inducible expression systems