Project: Soft and flexible technologies for electrical and optical modulation of the epileptic brain.

2022-01-01 – 2025-12-31

Abstract: Spatial and temporal targeting of dedicated brain regions is indispensable when treating brain disorders like epilepsy. This project develops a technology platform to bring targeted neuromodulation to epilepsy patients. Soft implantable probes will record epileptic activity and trigger a novel form of therapeutic neuromodulation based on light pulse delivery, controlled by a flexible electronic subcutaneous interface patch.

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- Journal Article
- A1
- open access
Photopharmacological activation of adenosine A1 receptor signaling suppresses seizures in a mouse model for temporal lobe epilepsy

Jeroen Spanoghe (UGent) , Evelien Wynendaele (UGent) , Marijke Vergaelen (UGent) , Maren De Colvenaer (UGent) , Tina Mariman, Kristl Vonck (UGent) , Evelien Carrette (UGent) , Wytse Wadman (UGent) , Erine Craey (UGent) , Lars Emil Larsen (UGent) , et al.

(2025) JOURNAL OF CONTROLLED RELEASE. 381.
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- Journal Article
- A2
- open access
Effects of intracerebroventricular administration of dimethyl sulfoxide on hippocampal electrophysiology in mice

Jeroen Spanoghe (UGent) , Arne Van Acker, Evelien Carrette (UGent) , Kristl Vonck (UGent) , Paul Boon (UGent) and Robrecht Raedt (UGent)

(2025) IBRO NEUROSCIENCE REPORTS. 18. p.378-383
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- Conference Paper
- C3
- open access
Towards therapeutic innovation in temporal lobe epilepsy : focal adenosinergic modulation of hippocampal excitability

Marijke Vergaelen (UGent) , Jeroen Spanoghe (UGent) , Jeroen Missinne (UGent) , Serge Van Calenbergh (UGent) , Kristl Vonck (UGent) , Paul Boon (UGent) and Robrecht Raedt (UGent)

(2024) EUROPEAN JOURNAL OF NEUROLOGY. In European Journal of Neurology 31(Supplement 1). p.296-297
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- Conference Paper
- C3
- open access
Photopharmacology in the spotlight : spatially selective adenosinergic modulation of hippocampal excitability in the pursuit of therapeutic innovation in temporal lobe epilepsy

Marijke Vergaelen (UGent) , Jeroen Spanoghe (UGent) , Jeroen Missinne (UGent) , Serge Van Calenbergh (UGent) , Paul Boon (UGent) , Kristl Vonck (UGent) and Robrecht Raedt (UGent)

(2024) FENS Forum 2024, Abstracts.
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- Journal Article
- A1
- open access
Quantitative analysis of the optogenetic excitability of CA1 neurons

Ruben Schoeters (UGent) , Thomas Tarnaud (UGent) , Laila Weyn (UGent) , Wout Joseph (UGent) , Robrecht Raedt (UGent) and Emmeric Tanghe (UGent)

(2023) FRONTIERS IN COMPUTATIONAL NEUROSCIENCE. 17.
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- Conference Paper
- C3
- open access
Soft, flexible, and biocompatible technologies for optical sensing and stimulation in biomedical applications

Jeroen Missinne (UGent) , Xavier De Becker (UGent) , Federico Pazzaglia (UGent) , Wouter Van Lysebettens (UGent) , Anastasiia Babych (UGent) , Jeroen Spanoghe (UGent) , Marijke Vergaelen (UGent) , Robrecht Raedt (UGent) , Pieter Bauwens (UGent) , Sandra Van Vlierberghe (UGent) , et al.

(2023) 2023 MRS Fall Meeting & Exhibit, Abstracts.
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- Journal Article
- A1
- open access
Auricular transcutaneous vagus nerve stimulation modulates the heart-evoked potential

Tasha Poppa, Lars Benschop, Paula Horczak (UGent) , Marie-Anne Vanderhasselt (UGent) , Evelien Carrette (UGent) , Antoine Bechara, Chris Baeken (UGent) and Kristl Vonck (UGent)

(2022) BRAIN STIMULATION. 15(1). p.260-269

Academic Bibliography

Project: Soft and flexible technologies for electrical and optical modulation of the epileptic brain.

Photopharmacological activation of adenosine A1 receptor signaling suppresses seizures in a mouse model for temporal lobe epilepsy

Effects of intracerebroventricular administration of dimethyl sulfoxide on hippocampal electrophysiology in mice

Towards therapeutic innovation in temporal lobe epilepsy : focal adenosinergic modulation of hippocampal excitability

Photopharmacology in the spotlight : spatially selective adenosinergic modulation of hippocampal excitability in the pursuit of therapeutic innovation in temporal lobe epilepsy

Quantitative analysis of the optogenetic excitability of CA1 neurons

Soft, flexible, and biocompatible technologies for optical sensing and stimulation in biomedical applications

Auricular transcutaneous vagus nerve stimulation modulates the heart-evoked potential

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