Project: Precision medicine in inherited blindness using integrated omics in human and animal models

2020-01-01 – 2026-10-31

Abstract

This multidisciplinary project aims (1) to decipher cis-­regulation in human retina by chromatin conformation profiling, and by the study of regulatory elements in a human and animal model;; (2) to design an integrative framework for omics data analysis to explain missing heritability in inherited
blindness;; (3) to design and test antisense oligonucleotide-­based treatments of novel targets, ultimately resulting in precision medicine for inherited blindness.