Project: Invasion of alphaherpesvirussen through respiratory mucosa, along neurons and via leukocytes
- project duration
- 01-JAN-06 – 31-OCT-11
- Invasion processes of alphaherpesviruses will be examined. It will be examined (i) which mechanisms alphaherpesviruses have developed to go through mucosal bariers, (ii) how neurons react on alphaherpesvirus infection in vitro en in vivo (which cellular changes, occur, how do they survive, how do they bring the virus in a latent stage, how do they reactivate the virus, what determines the reduced neuro-invasion with increasing age), (iii) how herpesvirus infected leukocytes become released in lymph nodes, circulate in blood and transmit virus at specific locations.