Project: Replication fork protector dependency factors: novel targets for combination treatment and immunomodulation in neuroblastoma (REINFORCE)

2022-01-01 – 2025-12-31

Abstract: This study aims to identify and explore novel therapeutic targets for combination therapy and immunomodulation in neuroblastoma, a pediatric tumor of the developing peripheral nervous system. The teams will collaboratively apply novel technology in functional cancer genetics, oncoimmunology, animal modeling and liquid biopsy analysis. This program will yield novel therapeutic strategies with better survival and reduced adverse side effects.

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- PhD Thesis
Development of a novel in situ capture spatial transcriptomics platform: design and implementation of a bioinformatics framework

Franco Alexander Poma Soto (UGent)

(2026)
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- Journal Article
- A1
- open access
Benchmarking DNA barcode decoding strategies under high error rates

Franco Alexander Poma Soto (UGent) , Hanne Van Droogenbroeck (UGent) , Brecht Soulliaert (UGent) , Maya Giridhar, Jürgen Behr, Hamed Sabzalipoor, Mark Somoza, Pieter Mestdagh (UGent) and Jo Vandesompele (UGent)

(2026) BMC BIOINFORMATICS. 27(1).
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- Journal Article
- A2
- open access
PeakPrime : a peak-guided primer design pipeline for target enrichment in 3′-end RNA-seq

Franco Alexander Poma Soto (UGent) , Brecht Soulliaert (UGent) , Hanne Van Droogenbroeck (UGent) , Pieter Mestdagh (UGent) and Jo Vandesompele (UGent)

(2026) BIOINFORMATICS ADVANCES. 6(1).
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- Journal Article
- A1
- open access
Synergistic inhibition of CHK1 and MUS81 to combat replication stress resistance in high-risk neuroblastoma

Elien Hilgert (UGent) , Christophe Van Neste (UGent) , Sarah-Lee Bekaert (UGent) , Fien Martens (UGent) , Suzanne Vanhauwaert (UGent) , Ellen Sanders (UGent) , Peter Verstraelen, Martijn Risseeuw (UGent) , Ellen M. Westerhout, Mark A. Grannetia, et al.

(2025) SCIENTIFIC REPORTS. 15(1).
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- Journal Article
- A1
- open access
MOXD1 is a lineage-specific gene and a tumor suppressor in neuroblastoma

Elina Fredlund, Stina Andersson, Elien Hilgert (UGent) , Ezequiel Monferrer, Guadalupe Álvarez-Hernán, Sinan Karakaya, Siebe Loontiens (UGent) , Jan Willem Bek (UGent) , Tomas Gregor, Estelle Lecomte, et al.

(2024) SCIENCE ADVANCES. 10(25).
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- Journal Article
- A1
- open access
NBAtlas : a harmonized single-cell transcriptomic reference atlas of human neuroblastoma tumors

Noah Bonine (UGent) , Vittorio Zanzani (UGent) , Annelies Van Hemelryk (UGent) , Bavo Vanneste (UGent) , Christian Zwicker (UGent) , Tinne THONE (UGent) , Sofie Roelandt (UGent) , Sarah-Lee Bekaert (UGent) , Jan Koster, Isabelle Janoueix-Lerosey, et al.

(2024) CELL REPORTS. 43(10).
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- Journal Article
- A1
- open access
Characterizing the cell-free transcriptome in a humanized diffuse large B-cell lymphoma patient-derived tumor xenograft model for RNA-based liquid biopsy in a preclinical setting

Philippe Decruyenaere (UGent) , Willem Daneels (UGent) , Annelien Morlion (UGent) , Kimberly Verniers (UGent) , Jasper Anckaert (UGent) , Jan Tavernier (UGent) , Fritz Offner (UGent) and Jo Vandesompele (UGent)

(2024) INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 25(18).
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- Journal Article
- A2
- open access
Leveraging a self-cleaving peptide for tailored control in proximity labeling proteomics

Louis Delhaye (UGent) , Georgios Moschonas (UGent) , Daria Fijalkowska (UGent) , Annick Verhee (UGent) , Delphine De Sutter (UGent) , Tessa Van de Steene (UGent) , Margaux De Meyer (UGent) , Hanna Grzesik (UGent) , Laura Van Moortel (UGent) , Karolien De Bosscher (UGent) , et al.

(2024) CELL REPORTS METHODS. 4(7).
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- Journal Article
- A2
- open access
Exploration of neuroblastoma xenograft models for tumor extracellular RNA profiling in murine blood plasma

Jill Deleu (UGent) , Hanne Van Droogenbroeck (UGent) , Jasper Anckaert (UGent) , Anneleen Decock (UGent) , Jilke De Wilde (UGent) , Kaat Durinck (UGent) , Liselot Mus (UGent) , Justine Nuytens (UGent) , Muhammad Rishfi (UGent) , Kathleen Schoofs (UGent) , et al.

(2023) EXRNA. 5(2).
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- Journal Article
- A1
- open access
Exploring the cell-free total RNA transcriptome in diffuse large B-cell lymphoma and primary mediastinal B-cell lymphoma patients as biomarker source in blood plasma liquid biopsies

Philippe Decruyenaere (UGent) , Edoardo Giuili, Kimberly Verniers (UGent) , Jasper Anckaert (UGent) , Katrien De Grove (UGent) , Malaïka Van der Linden (UGent) , Dries Deeren, Jo Van Dorpe (UGent) , Fritz Offner (UGent) and Jo Vandesompele (UGent)

(2023) FRONTIERS IN ONCOLOGY. 13.

Academic Bibliography

Project: Replication fork protector dependency factors: novel targets for combination treatment and immunomodulation in neuroblastoma (REINFORCE)

Development of a novel in situ capture spatial transcriptomics platform: design and implementation of a bioinformatics framework

Benchmarking DNA barcode decoding strategies under high error rates

PeakPrime : a peak-guided primer design pipeline for target enrichment in 3′-end RNA-seq

Synergistic inhibition of CHK1 and MUS81 to combat replication stress resistance in high-risk neuroblastoma

MOXD1 is a lineage-specific gene and a tumor suppressor in neuroblastoma

NBAtlas : a harmonized single-cell transcriptomic reference atlas of human neuroblastoma tumors

Characterizing the cell-free transcriptome in a humanized diffuse large B-cell lymphoma patient-derived tumor xenograft model for RNA-based liquid biopsy in a preclinical setting

Leveraging a self-cleaving peptide for tailored control in proximity labeling proteomics

Exploration of neuroblastoma xenograft models for tumor extracellular RNA profiling in murine blood plasma

Exploring the cell-free total RNA transcriptome in diffuse large B-cell lymphoma and primary mediastinal B-cell lymphoma patients as biomarker source in blood plasma liquid biopsies

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