Project: Replication fork protector dependency factors: novel targets for combination treatment and immunomodulation in neuroblastoma (REINFORCE)

2022-01-01 – 2025-12-31

Abstract: This study aims to identify and explore novel therapeutic targets for combination therapy and immunomodulation in neuroblastoma, a pediatric tumor of the developing peripheral nervous system. The teams will collaboratively apply novel technology in functional cancer genetics, oncoimmunology, animal modeling and liquid biopsy analysis. This program will yield novel therapeutic strategies with better survival and reduced adverse side effects.

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- Journal Article
- A1
- open access
NBAtlas : a harmonized single-cell transcriptomic reference atlas of human neuroblastoma tumors

Noah Bonine (UGent) , Vittorio Zanzani (UGent) , Annelies Van Hemelryk (UGent) , Bavo Vanneste (UGent) , Christian Zwicker (UGent) , Tinne Thoné (UGent) , Sofie Roelandt (UGent) , Sarah-Lee Bekaert (UGent) , Jan Koster, Isabelle Janoueix-Lerosey, et al.

(2024) CELL REPORTS. 43(10).
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- Journal Article
- A1
- open access
Characterizing the cell-free transcriptome in a humanized diffuse large B-cell lymphoma patient-derived tumor xenograft model for RNA-based liquid biopsy in a preclinical setting

Philippe Decruyenaere (UGent) , Willem Daneels (UGent) , Annelien Morlion (UGent) , Kimberly Verniers (UGent) , Jasper Anckaert (UGent) , Jan Tavernier (UGent) , Fritz Offner (UGent) and Jo Vandesompele (UGent)

(2024) INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 25(18).
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- Journal Article
- A2
- open access
Leveraging a self-cleaving peptide for tailored control in proximity labeling proteomics

Louis Delhaye (UGent) , Georgios Moschonas (UGent) , Daria Fijalkowska (UGent) , Annick Verhee (UGent) , Delphine De Sutter (UGent) , Tessa Van de Steene (UGent) , Margaux De Meyer (UGent) , Hanna Grzesik (UGent) , Laura Van Moortel (UGent) , Karolien De Bosscher (UGent) , et al.

(2024) CELL REPORTS METHODS. 4(7).
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- Journal Article
- A2
- open access
Exploration of neuroblastoma xenograft models for tumor extracellular RNA profiling in murine blood plasma

Jill Deleu (UGent) , Hanne Van Droogenbroeck (UGent) , Jasper Anckaert (UGent) , Anneleen Decock (UGent) , Jilke De Wilde (UGent) , Kaat Durinck (UGent) , Liselot Mus (UGent) , Justine Nuytens (UGent) , Muhammad Rishfi (UGent) , Kathleen Schoofs (UGent) , et al.

(2023) EXRNA. 5(2).
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- Journal Article
- A1
- open access
Exploring the cell-free total RNA transcriptome in diffuse large B-cell lymphoma and primary mediastinal B-cell lymphoma patients as biomarker source in blood plasma liquid biopsies

Philippe Decruyenaere (UGent) , Edoardo Giuili, Kimberly Verniers (UGent) , Jasper Anckaert (UGent) , Katrien De Grove (UGent) , Malaïka Van der Linden (UGent) , Dries Deeren, Jo Van Dorpe (UGent) , Fritz Offner (UGent) and Jo Vandesompele (UGent)

(2023) FRONTIERS IN ONCOLOGY. 13.
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- Journal Article
- A1
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RNA extraction method impacts quality metrics and sequencing results in formalin-fixed, paraffin-embedded tissue samples

Philippe Decruyenaere (UGent) , Kimberly Verniers (UGent) , Franco Alexander Poma Soto (UGent) , Jo Van Dorpe (UGent) , Fritz Offner (UGent) and Jo Vandesompele (UGent)

(2023) LABORATORY INVESTIGATION. 103(2).
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- Journal Article
- A2
- open access
Whole transcriptome profiling of liquid biopsies from tumour xenografted mouse models enables specific monitoring of tumour-derived extracellular RNA

Vanessa Vermeirssen (UGent) , Jill Deleu (UGent) , Annelien Morlion (UGent) , Celine Everaert (UGent) , Jilke De Wilde (UGent) , Jasper Anckaert (UGent) , Kaat Durinck (UGent) , Justine Nuytens (UGent) , Muhammad Rishfi (UGent) , Franki Speleman (UGent) , et al.

(2022) NAR CANCER. 4(4).
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- Journal Article
- A1
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RRM2 enhances MYCN-driven neuroblastoma formation and acts as a synergistic target with CHK1 inhibition

Carolina de Carvalho Nunes, Lisa Depestel (UGent) , Liselot Mus (UGent) , Kaylee M. Keller, Louis Delhaye (UGent) , Amber Louwagie (UGent) , Muhammad Rishfi (UGent) , Alex Whale, Neesha Kara, Simon R. Andrews, et al.

(2022) SCIENCE ADVANCES. 8(28).

Academic Bibliography

Project: Replication fork protector dependency factors: novel targets for combination treatment and immunomodulation in neuroblastoma (REINFORCE)

NBAtlas : a harmonized single-cell transcriptomic reference atlas of human neuroblastoma tumors

Characterizing the cell-free transcriptome in a humanized diffuse large B-cell lymphoma patient-derived tumor xenograft model for RNA-based liquid biopsy in a preclinical setting

Leveraging a self-cleaving peptide for tailored control in proximity labeling proteomics

Exploration of neuroblastoma xenograft models for tumor extracellular RNA profiling in murine blood plasma

Exploring the cell-free total RNA transcriptome in diffuse large B-cell lymphoma and primary mediastinal B-cell lymphoma patients as biomarker source in blood plasma liquid biopsies

RNA extraction method impacts quality metrics and sequencing results in formalin-fixed, paraffin-embedded tissue samples

Whole transcriptome profiling of liquid biopsies from tumour xenografted mouse models enables specific monitoring of tumour-derived extracellular RNA

RRM2 enhances MYCN-driven neuroblastoma formation and acts as a synergistic target with CHK1 inhibition

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