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Project: Analysis of the functional role of EMT target gens in epithelial differentiation and malignant cancer progression

01-OCT-06 – 30-SEP-08

During epithelial-mesenchymal transition (EMT) epithelial cells lose their apico-basal polarity, resulting in a fibroblastic-like, migrating phenotype. Two EMT target genes, ELF3 and PLAB, are investigated for their role in epithelial differentiation and invasion and metastasis during cancer progression. Manipulation of their gene expression (repression/overexpression), studies on transcriptional regulation and the development of an in vivo mouse model will be performed.