Project: Identification and signal transduction analyses of direct and miRNA regulated MYCN targets in neuroblastoma
- project duration
- 01-OCT-06 – 30-SEP-10
- Neuroblastoma is the most frequent extracranial solid tumour in children. Despite the existence of multimodal treatments, the prognosis of most patients remains unfavourable. A subgroup of aggressive neuroblastoma tumours is characterised by amplification of the MYCN transcription factor. The identification of new MYCN target genes could result in improved treatment stategies.