Project: Elucidation of the genetic defect in sporadic melorheostosis and study of the precise role of LEMD3 in bone homeostasis
- project duration
- 01-JAN-09 – 31-DEC-12
- This project aims to identify the genetic defect in sporadic melorheostosis. In addition we aim to gain more insights into the precise role of LEMD3 in TGFbeta/BMP signaling and regulation of bone density. For this study we will use several approaches including yeast two hybrid experiments, ChIP-seq, a transgenic mouse model and whole-exome sequencing.