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Project: Analysis of attenuation of leptin signaling

01-OCT-05 – 30-SEP-07

Leptin plays a crucial role in fat metabolism and functions as an adipostat at the level of the hypothalamic neurocircuitry. Besides these central functions, leptin also has several functions on peripheral cell types and evidence for a pathological role in autoimmune diseases is accumulating. In this program, we aim at investigating feedback mechanisms controlling leptin receptor activation.