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Project: Aspects of the porcine arterivirus replication cycle in macrophages leading to immune-evasion

01-OCT-04 – 30-SEP-08

Some potential immune-evasive mechanisms of the porcine arterivirus, which specifically targets macrophages, will be studied in this project. It will be investigated if the absence of viral proteins on the cell surface protects infected macrophages against antibody-dependent cell death. Also, it will be investigated if the potential spreading of the virus via apoptotic bodies is a new immune-evasion mechanism.