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Project: A detailed study of the protection of matrix metalloproteinase-9 (MMP-9) against tumor necrosis factor induced lethal shock

01-OCT-02 – 31-DEC-02

With this research project we whish to study the role of MMP-9 in a systematic inflammation model induced by TNF. Previous research revealed that MMP-9 deficient mice are very susceptible towards TNF, which makes this MMP an anti-inflammatory protease. Furthermore, we will also study the role of MMP-9 in an antitumormodel based on TNF and IFNy.