Project: Triple bioassays for dual purpose: Doping Control & Cancer Research
2020-11-01 – 2024-09-15
- Abstract
This project proposal aims at developing novel 'untargeted' bioassays that allow dynamic monitoring of protein-protein interactions (PPIs) within the oxygen sensing hypoxia-inducible factor (HIF)-pathway. Three PPIs will be studied/targeted in the context of doping and cancer research:
HIF1a-HIF1b heterodimerization, the interaction between HIF1a and the Von Hippel Lindau tumor suppressor protein (pVHL) and the interaction between HIF1a and coactivator p300.
Show
Sort by
-
Review on activity-based detection of doping substances and growth promotors in biological matrices: do bioassays deserve a place in control programs?
-
The 'ABC' of split-nanoluciferase HIF heterodimerization bioassays: Applications, Benefits & Considerations
-
Interpreting mono- and poly-SCRA intoxications from an activity-based point of view: JWH-018 equivalents in serum as a comparative measure
-
- Journal Article
- A1
- open access
Investigation of the intrinsic cannabinoid activity of hemp-derived and semisynthetic cannabinoids with β-arrestin2 recruitment assays-and how this matters for the harm potential of seized drugs
-
- Journal Article
- A1
- open access
Untargeted detection of HIF stabilizers in doping samples : activity-based screening with a stable in vitro bioassay
-
- Journal Article
- A1
- open access
Comprehensive characterization of a systematic library of alkyl and alicyclic synthetic cannabinoids related to CUMYL-PICA, CUMYL-BUTICA, CUMYL-CBMICA, and CUMYL-PINACA
-
- Journal Article
- A1
- open access
Linking in vitro and ex vivo CB1 activity with serum concentrations and clinical features in 5F-MDMB-PICA users to better understand SCRAs and their metabolites
-
Machine learning to assist in large-scale, activity-based synthetic cannabinoid receptor agonist screening of serum samples