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Project: Genetic manipulation of Lactococcus lactis in order to improve the in vivo administration of biologically active macromolecules.

01-OCT-95 – 31-DEC-99

The molecular adaptation of Lactococcus lactis aims at : 1. more efficient and experimentally controlable colonization at the level of the mucosa 2. fine tuning of the expression of heterologous genes with emphasis on the use of cytokines as adjuvantia.