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Project: Quantitative proteomic analysis of MYCN oncoprotein function and screening for molecularly therapeutical targets in neuroblastoma

2004-10-01 – 2008-09-30

Abstract

The most aggressive subgroup of neuroblastoma tumours is characterized by amplification of the MYCN oncoprotein. In this project both modulable cell model systems and extensive arrays of neuroblastoma tumours will be analyzed at the proteomic level with a view to acquiring insight into the MYCN deregulated signaling pathways in neuroblastoma and to identifying new targets for molecularly therapeutical intervention.