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Project: Analysis of Signal Transduction by the type I Interferon Receptor Complex.

01-OCT-01 – 30-SEP-03

Cells respond to virus infection by activation of various IFN genes and IFN stimulated genes. Interferon Regulatory Factors (IRFs) play a crucial role in the induction of an antiviral response by the type I IFN family. The MAPPIT system (Mammalian Protein-Protein Interaction Trap) offers a convenient tool to identify and analyze interaction-partners of the IRFs and other signal molecules. This two-hybrid strategy in human cells exploits the advantage of working in a relevant physiological environment.