Project: Identification and Functional Analysis of Candidate MYCN Transcriptional Target Genes and Molecular Delineation of the 11q13 Amplicon in Neuroblastoma
- project duration
- 01-OCT-02 – 31-DEC-06
- Neuroblastoma is the most frequent extracranial solid tumour in children. Despite the existence of multimodal treatments, the prognosis of most patients remains unfavourable. A subgroup of aggressive neuroblastoma tumours is characterised by amplification of the MYCN transcription factor. The identification of new MYCN target genes could result in improved treatment stategies.