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Project: Analysis of signal transduction via the leptin receptor using a novel two-hybrid system.

01-OCT-01 – 30-SEP-03

Abstract
Within the framework of the leptin signal transduction research we are searching for leptin receptor associating proteins using the MAPPIT technology (mammalian protein-protein interaction trap) and cDNA libraries of hypothalamic tissue and the hybrid hypothalamic cell line FIIHY14. Bindingscharacteristics of identified interaction partners will be studied and functional relevance for leptin signal transduction and leptin resistance will be verified.