Project: Intracellular mechanisms associated with 'reverse signaling' of membrane TNF.
- project duration
- 01-OCT-01 – 30-SEP-03
- TNF is a protein involved in inflammatory processes in humans. When TNF binds its receptor, a signal in the receptor expressing cell is delivered. On the other hand, there is also a 'reverse signal' into the TNF expressing cell. This could function as a negative feedback of the response. In this project, we want to search for the mechanisms involved.