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Project: Rheumatoid arthritis: identification of serological risk factors (auto-antibodies, genotypes and markers in the synovial membrane) for progression of anatomical damage.

2001-10-01 – 2003-09-30

Abstract

The aim of this research is: 1. To improve the analysis of serological riskfactors (e.g. anti-citrulline auto-antibodies and anti-filaggrine auto-antibodies). 2. To assess the importance of the shared epitope, cytokines and cytokine-receptors. 3. To identify citrullinated proteins and other, new antigens in the synovium: immunohistochemical analysis and Westrn immunoblotting. The diagnostic and prognostic relevance of these biological risk factors will be investigated.