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Project: Immune evasion of infected leukocytes and their role in herpesvirus abortion in horses

project duration
01-OCT-02 – 30-SEP-04
abstract
Equine herpesvirus 1 (EHV1) can cause abortion in infection-immune horses. Of major importace in the patogenese zijn de geïnfecteerde bloedleukocyten zonder virale eiwitexpressie op hun plasma membrane. The aims of the proposed project are (1) to examine how EHV1 prevents the expression of viral antigens on the plasma membrane and (2) to study the interaction of the immune evasive leukocytes with endothelial cells of the uterine blood vessels in vitro and in vivo.