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Project: Eosinophilic inflammation and expression of human 5 receptor alpha-subunit isoforms in nasal polyposis.

project duration
01-OCT-00 – 30-SEP-02
abstract
The interleukin 5 receptor alpha-subunit occurs either as a signalling, membrane-anchored isoform, or as a secreted, antagonistic variant. Given the key role of interleukin 5 in processes leading to differentiation and activation of eosinophils, a cell type critically involved in nasal polyposis, we will investigate this isoform expression pattern in human nasal polyposis in vivo and in vitro cell cultures.