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Project: Analysis of the alternative splicing pattern of the human interleukin 5 alpha-receptor using reporte systems.

01-JUL-97 – 31-DEC-99

In this program we plan to determine the alternative splicing pattern of transcripts of the human interleukin-5- alpha-receptor gene. Via this mechanism, either a secreted or a membrane-anchored receptor variant can be generated. We will use minigene-constructs in which coding regions for interleukin-6 or luciferase are coupled to the extracellular or cytoplasmic regions of IL5Ra respectively. This will allows efficient analysis of the isoform expression pattern.