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Project: A functional, morphological and pharmacological in vivo and in vitro study of vascular lesions after acute renal failure, using an ischemic and a nephrotoxic model.

project duration
01-JAN-00 – 31-DEC-99
abstract
The influence of an in vivo and in vitro experimentally induced acute tubular necrosis will be explored on vascular and tubular morphology, renal function and hemodynamics, vascular reactivity, intracellular signal transduction mechanismsin vascularendothelial and smooth muscle cells, and on the release of vasoactive substances from vascular tissue. In addition the reversibility of the possible changes will be studied.