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Project: Evaluation of chromosomal radiosensitivity in breastcancer patients and study of the underlying genetic mechanisms.

project duration
01-JAN-01 – 31-OCT-03
abstract
The overall theme of the proposed project is to examine the relationship between chromosomal radiosensitivity, underlying genetic mechanisms which influence the individual radiation response and breastcancer predisposition. The G2-assay (chromatid breaks) and 'low dose rate' micronucleus assay (chromosome fragments) will be used as cytogenetic methods to identify radiosensitive breastcancer patients. On a selected group of radiosensitive and normal responding breastcancer patients underlying mechanisms of chromosomal radiosensitivity will be studied. For this aim mRNA transcription, protein expression and microsatellite polymorphisms of DNA repair genes will be analysed.