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Project: Optimisation of assisted oocyte activation in ICSI by studying Ca - oscillation patterns

project duration
01-JAN-04 – 31-JAN-09
abstract
Failure of fertilisation after ICSI is mainly due to failure of oocyte activation. Artificial oocyte activation can be applied. We study: 1) selection of the most physiological activation stimulus by means of Ca - oscillation pattern and mouse oocyte developmental potential 2) effect of the selected activation during heterologous ICSI with human activation-deficient spermatozoa 3) safety assessment: mouse post-implantation development.