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Project: Effect of periparturient leukocyte function on the detoxification of bacterial endotoxins in cows.

project duration
01-JAN-96 – 31-DEC-99
abstract
The aim of the proposed research project is to investigate the detoxification of endotoxins by leukocytes in lactating cows.Healthy and infected animals will be used to study 1. the CD14 receptor and 2. the acyloxyacyl hydrolase activity of leukocytes. Experiments 'in vitro' will be performed to study the effect of LPS, the LPS binding protein and glucocorticosteroids on the expression of the CD10-, CD14- and CD18/C11-receptor on leukocytes.