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Project: A detailed study of the ontogeny and function of TCR gamma delta cells.

01-JAN-97 – 31-OCT-01

Murine Vgamma3 cells are a T cell subpopulation of clonal nature. We will investigate if Vgamma3 cells are thymus dependent, if they are comparable to NK Cells, if these cells influence dendritic cells, and we will perform a detailed study on the mechanisms of activation of these cells by lipopolysaccharide. Finally, the ontogeny and function of human gamma delta cells will be studied.